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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3610
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rxra
Name: retinoid X receptor alpha
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rxradecreases expressionISORXRA (Homo sapiens)6480464CTDGenistein results in decreased expression of RXRA mRNAPMID:20706672
Rxramultiple interactionsISORXRA (Homo sapiens)6480464CTDGenistein promotes the reaction [RXRA protein binds to ABCC2 promoter]; resveratrol inhibits the reaction [Genistein promotes the reaction [RXRA protein binds to ABCC2 promoter]]PMID:21689630
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