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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3610
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rxra
Name: retinoid X receptor alpha
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rxraaffects localizationISORxra (Mus musculus)6480464CTDLipopolysaccharides affects the localization of RXRA proteinPMID:17107731
Rxradecreases activityISORxra (Mus musculus)6480464CTDLipopolysaccharides results in decreased activity of RXRA proteinPMID:12388159
Rxradecreases expressionISORxra (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of RXRA mRNA; Lipopolysaccharides results in decreased expression of RXRA proteinPMID:12388159 PMID:16002565 PMID:16847310
Rxradecreases expressionISORXRA (Homo sapiens)6480464CTDLipopolysaccharides results in decreased expression of RXRA mRNAPMID:35811015
Rxradecreases localizationISORxra (Mus musculus)6480464CTDLipopolysaccharides results in decreased localization of RXRA proteinPMID:15312234
Rxramultiple interactionsISORxra (Mus musculus)6480464CTDrosiglitazone affects the reaction [Lipopolysaccharides affects the localization of RXRA protein]PMID:17107731
Rxramultiple interactionsISORXRA (Homo sapiens)6480464CTD[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of RXRA mRNAPMID:35811015
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