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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3610
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rxra
Name: retinoid X receptor alpha
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rxraaffects localizationEXP 6480464CTDTretinoin affects the localization of RXRA proteinPMID:17078027
Rxraincreases expressionEXP 6480464CTDTretinoin results in increased expression of RXRA mRNA; Tretinoin results in increased expression of RXRA proteinPMID:24977338 PMID:26672737
Rxramultiple interactionsEXP 6480464CTDTretinoin promotes the reaction [nitrofen results in increased expression of RXRA mRNA]PMID:26672737
Rxraaffects bindingISORxra (Mus musculus)6480464CTD[Tretinoin binds to RXRA protein] which binds to NRL promoterPMID:16854989
Rxraaffects bindingISORXRA (Homo sapiens)6480464CTD[Tretinoin binds to [RXRA protein binds to RARA protein]] which binds to PDK4 promoter; Tretinoin binds to [RXRA protein binds to RARA protein]; Tretinoin binds to RXRA proteinPMID:16757381 PMID:23843199 PMID:31566444
Rxraaffects localizationISORXRA (Homo sapiens)6480464CTDTretinoin affects the localization of RXRA proteinPMID:16636311
Rxradecreases expressionISORxra (Mus musculus)6480464CTDTretinoin results in decreased expression of RXRA proteinPMID:15646024
Rxradecreases expressionISORXRA (Homo sapiens)6480464CTDTretinoin results in decreased expression of RXRA proteinPMID:15194426 PMID:15375546
Rxradecreases phosphorylationISORXRA (Homo sapiens)6480464CTDTretinoin results in decreased phosphorylation of RXRA proteinPMID:15126328
Rxraincreases activityISORxra (Mus musculus)6480464CTDTretinoin results in increased activity of RXRA proteinPMID:20035057
Rxraincreases activityISORXRA (Homo sapiens)6480464CTDTretinoin results in increased activity of RXRA proteinPMID:21543282 PMID:27131391 PMID:30639747
Rxraincreases expressionISORXRA (Homo sapiens)6480464CTDTretinoin results in increased expression of RXRA mRNA; Tretinoin results in increased expression of RXRA proteinPMID:16517099 PMID:16636311 PMID:17005281 PMID:20507312 PMID:7556191
Rxraincreases phosphorylationISORXRA (Homo sapiens)6480464CTDTretinoin results in increased phosphorylation of RXRA proteinPMID:15225641
Rxramultiple interactionsISORxra (Mus musculus)6480464CTD[Tretinoin results in increased activity of RXRA protein] which results in increased expression of CCNE1 mRNA; Tretinoin promotes the reaction [[RARG protein binds to RXRA protein] which binds to CYP26A1 promoter]PMID:16053444 PMID:20035057
Rxramultiple interactionsISORXRA (Homo sapiens)6480464CTD[Cholecalciferol co-treated with Tretinoin] promotes the reaction [[VDR protein binds to RXRA protein] which binds to SLCO1A2 promoter]; [RARA protein binds to RXRA protein] promotes the reaction [Tretinoin results in increased degradation of NCOA3 protein]; [Tretinoin co-treated with alpha-Tocopherol co-treated with Okadaic Acid] results in decreased phosphorylation of RXRA protein; [Tretinoin co-treated with alpha-Tocopherol] results in decreased phosphorylation of RXRA protein; [Tretinoin co-treated with bisindolylmaleimide I] results in decreased phosphorylation of RXRA protein; [Tretinoin co-treated with calphostin C] results in decreased phosphorylation of RXRA protein; [Tretinoin co-treated with RARA protein co-treated with RXRA protein] results in increased expression of CYP26A1 mRNA; [Tretinoin results in increased sumoylation of and results in decreased degradation of RARA protein] promotes the reaction [RARA protein binds to RXRA protein]; [Tretinoin results in increased ubiquitination of and results in increased degradation of RARA protein] inhibits the reaction [RARA protein binds to RXRA protein]; leptomycin B inhibits the reaction [Tretinoin affects the localization of [NR4A1 protein binds to RXRA protein]]; RXRA promotes the reaction [Tretinoin results in increased expression of APOA2 mRNA]; RXRA protein promotes the reaction [Tretinoin results in increased expression of SOX3 mRNA]; RXRA protein promotes the reaction [Tretinoin results in increased expression of SOX3 protein]; Tretinoin affects the localization of [NR4A1 protein binds to RXRA protein]; Tretinoin analog binds to and results in increased activity of RXRA protein; Tretinoin binds to and results in increased activity of RXRA protein; Tretinoin promotes the reaction [[RARA protein binds to RXRA protein] which binds to NOS2A promoter]; Tretinoin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Tretinoin promotes the reaction [Etoposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]]; Tretinoin promotes the reaction [RXRA protein binds to CD1D promoter]; Tretinoin promotes the reaction [RXRA protein results in increased expression of CETP mRNA]; Tretinoin promotes the reaction [salvin results in increased expression of RXRA protein]; Tretinoin promotes the reaction [Teniposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]]; Tretinoin results in increased activity of [NR4A1 protein binds to RXRA protein]; Tretinoin results in increased activity of [RARA protein binds to RXRA protein]; Tretinoin results in increased activity of [RARG protein binds to RXRA protein]; Tretinoin results in increased expression of and results in increased activity of RXRA protein; ZNF366 protein promotes the reaction [Tretinoin results in increased activity of [RARA protein binds to RXRA protein]]PMID:11504768 PMID:14592536 PMID:15171703 PMID:15225641 PMID:16158052 PMID:16456540 PMID:16632523 PMID:16946489 PMID:17005281 PMID:17244623 PMID:17306764 PMID:17392484 PMID:20008677 PMID:22474172 PMID:25914138 PMID:30639747 PMID:8668150
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