GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Rxra | affects localization | EXP | | 6480464 | CTD | Tretinoin affects the localization of RXRA protein | PMID:17078027 | Rxra | increases expression | EXP | | 6480464 | CTD | Tretinoin results in increased expression of RXRA mRNA; Tretinoin results in increased expression of RXRA protein | PMID:24977338 PMID:26672737 | Rxra | multiple interactions | EXP | | 6480464 | CTD | Tretinoin promotes the reaction [nitrofen results in increased expression of RXRA mRNA] | PMID:26672737 | Rxra | affects binding | ISO | Rxra (Mus musculus) | 6480464 | CTD | [Tretinoin binds to RXRA protein] which binds to NRL promoter | PMID:16854989 | Rxra | affects binding | ISO | RXRA (Homo sapiens) | 6480464 | CTD | [Tretinoin binds to [RXRA protein binds to RARA protein]] which binds to PDK4 promoter; Tretinoin binds to [RXRA protein binds to RARA protein]; Tretinoin binds to RXRA protein | PMID:16757381 PMID:23843199 PMID:31566444 | Rxra | affects localization | ISO | RXRA (Homo sapiens) | 6480464 | CTD | Tretinoin affects the localization of RXRA protein | PMID:16636311 | Rxra | decreases expression | ISO | Rxra (Mus musculus) | 6480464 | CTD | Tretinoin results in decreased expression of RXRA protein | PMID:15646024 | Rxra | decreases expression | ISO | RXRA (Homo sapiens) | 6480464 | CTD | Tretinoin results in decreased expression of RXRA protein | PMID:15194426 PMID:15375546 | Rxra | decreases phosphorylation | ISO | RXRA (Homo sapiens) | 6480464 | CTD | Tretinoin results in decreased phosphorylation of RXRA protein | PMID:15126328 | Rxra | increases activity | ISO | Rxra (Mus musculus) | 6480464 | CTD | Tretinoin results in increased activity of RXRA protein | PMID:20035057 | Rxra | increases activity | ISO | RXRA (Homo sapiens) | 6480464 | CTD | Tretinoin results in increased activity of RXRA protein | PMID:21543282 PMID:27131391 PMID:30639747 | Rxra | increases expression | ISO | RXRA (Homo sapiens) | 6480464 | CTD | Tretinoin results in increased expression of RXRA mRNA; Tretinoin results in increased expression of RXRA protein | PMID:16517099 PMID:16636311 PMID:17005281 PMID:20507312 PMID:7556191 | Rxra | increases phosphorylation | ISO | RXRA (Homo sapiens) | 6480464 | CTD | Tretinoin results in increased phosphorylation of RXRA protein | PMID:15225641 | Rxra | multiple interactions | ISO | Rxra (Mus musculus) | 6480464 | CTD | [Tretinoin results in increased activity of RXRA protein] which results in increased expression of CCNE1 mRNA; Tretinoin promotes the reaction [[RARG protein binds to RXRA protein] which binds to CYP26A1 promoter] | PMID:16053444 PMID:20035057 | Rxra | multiple interactions | ISO | RXRA (Homo sapiens) | 6480464 | CTD | [Cholecalciferol co-treated with Tretinoin] promotes the reaction [[VDR protein binds to RXRA protein] which binds to SLCO1A2 promoter]; [RARA protein binds to RXRA protein] promotes the reaction [Tretinoin results in increased degradation of NCOA3 protein]; [Tretinoin co-treated with alpha-Tocopherol co-treated with Okadaic Acid] results in decreased phosphorylation of RXRA protein; [Tretinoin co-treated with alpha-Tocopherol] results in decreased phosphorylation of RXRA protein; [Tretinoin co-treated with bisindolylmaleimide I] results in decreased phosphorylation of RXRA protein; [Tretinoin co-treated with calphostin C] results in decreased phosphorylation of RXRA protein; [Tretinoin co-treated with RARA protein co-treated with RXRA protein] results in increased expression of CYP26A1 mRNA; [Tretinoin results in increased sumoylation of and results in decreased degradation of RARA protein] promotes the reaction [RARA protein binds to RXRA protein]; [Tretinoin results in increased ubiquitination of and results in increased degradation of RARA protein] inhibits the reaction [RARA protein binds to RXRA protein]; leptomycin B inhibits the reaction [Tretinoin affects the localization of [NR4A1 protein binds to RXRA protein]]; RXRA promotes the reaction [Tretinoin results in increased expression of APOA2 mRNA]; RXRA protein promotes the reaction [Tretinoin results in increased expression of SOX3 mRNA]; RXRA protein promotes the reaction [Tretinoin results in increased expression of SOX3 protein]; Tretinoin affects the localization of [NR4A1 protein binds to RXRA protein]; Tretinoin analog binds to and results in increased activity of RXRA protein; Tretinoin binds to and results in increased activity of RXRA protein; Tretinoin promotes the reaction [[RARA protein binds to RXRA protein] which binds to NOS2A promoter]; Tretinoin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Tretinoin promotes the reaction [Etoposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]]; Tretinoin promotes the reaction [RXRA protein binds to CD1D promoter]; Tretinoin promotes the reaction [RXRA protein results in increased expression of CETP mRNA]; Tretinoin promotes the reaction [salvin results in increased expression of RXRA protein]; Tretinoin promotes the reaction [Teniposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]]; Tretinoin results in increased activity of [NR4A1 protein binds to RXRA protein]; Tretinoin results in increased activity of [RARA protein binds to RXRA protein]; Tretinoin results in increased activity of [RARG protein binds to RXRA protein]; Tretinoin results in increased expression of and results in increased activity of RXRA protein; ZNF366 protein promotes the reaction [Tretinoin results in increased activity of [RARA protein binds to RXRA protein]] | PMID:11504768 PMID:14592536 PMID:15171703 PMID:15225641 PMID:16158052 PMID:16456540 PMID:16632523 PMID:16946489 PMID:17005281 PMID:17244623 PMID:17306764 PMID:17392484 PMID:20008677 PMID:22474172 PMID:25914138 PMID:30639747 PMID:8668150 | |
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