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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3554
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ren
Name: renin
Acc ID: CHEBI:6343
Term: labetalol
Definition: A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.
Chemical ID: MESH:D007741
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rendecreases activityISOREN (Homo sapiens)6480464CTDLabetalol results in decreased activity of REN proteinPMID:2524958 PMID:7013770 PMID:7988622
Renmultiple interactionsISOREN (Homo sapiens)6480464CTD[Labetalol co-treated with Isoflurane] results in increased expression of REN proteinPMID:1897344
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