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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3540 Species: Rattus norvegicus RGD Object: Gene Symbol: Rb1 Name: retinoblastoma 1

Acc ID: CHEBI:45713 Term: trans-resveratrol Definition: A resveratrol that has formula C14H12O3. CasRN: 501-36-0 Chemical ID: MESH:C059514

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases phosphorylation	ISO	RGD:731712	6480464	CTD	resveratrol results in decreased phosphorylation of RB1 protein	PMID:16761963 PMID:17804729
affects expression	ISO	RGD:11219	6480464	CTD	resveratrol affects the expression of RB1 mRNA resveratrol affects the expression of RB1 protein	PMID:16369916
decreases phosphorylation	ISO	RGD:731712	6480464	CTD	resveratrol results in decreased phosphorylation of RB1 protein	PMID:17804729 PMID:16761963
decreases phosphorylation	ISO	RGD:731712	6480464	CTD	resveratrol results in decreased phosphorylation of RB1 protein	PMID:16761963 PMID:17804729 PMID:18347188
decreases phosphorylation	ISO	RGD:731712	6480464	CTD	resveratrol results in decreased phosphorylation of RB1 protein	PMID:11481417 PMID:16761963 PMID:17804729 PMID:18347188 PMID:19559722 PMID:20028382
decreases expression	EXP		6480464	CTD	resveratrol results in decreased expression of RB1 protein modified form	PMID:22104698