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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3534
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rara
Name: retinoic acid receptor, alpha
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Raramultiple interactionsEXP 6480464CTD[Valproic Acid co-treated with Vitamin A deficiency] affects the expression of RARA protein; [Valproic Acid co-treated with Vitamin A deficiency] affects the reaction [RARA protein binds to RET promoter]PMID:32526256
Raradecreases methylationISORARA (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of RARA genePMID:28853863 PMID:29201983
Raraincreases expressionISORara (Mus musculus)6480464CTDValproic Acid results in increased expression of RARA mRNAPMID:15799026
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