A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID:
MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
IL1B protein promotes the reaction [Tretinoin affects the localization of RARA protein]; Tretinoin inhibits the reaction [nitrofen results in decreased expression of RARA protein]; Tretinoin inhibits the reaction [nitrofen results in increased expression of RARA protein]; Tretinoin promotes the reaction [nitrofen results in increased expression of RARA mRNA]
[Tretinoin binds to [RXRA protein binds to RARA protein]] which binds to PDK4 promoter; Tretinoin binds to [RXRA protein binds to RARA protein]; Tretinoin binds to RARA protein
Tretinoin results in increased expression of RARA mRNA; Tretinoin results in increased expression of RARA mRNA alternative form; Tretinoin results in increased expression of RARA protein
RARA protein affects the reaction [Tretinoin affects the expression of CYP26A1 mRNA]; RARA protein affects the reaction [Tretinoin affects the expression of RARB mRNA]; RARA protein inhibits the reaction [Tretinoin results in increased activity of [CLOCK protein binds to BMAL1 protein]]; Tretinoin binds to and results in increased activity of RARA protein; Tretinoin inhibits the reaction [RARA gene mutant form results in decreased expression of KRT19 mRNA]; Tretinoin inhibits the reaction [RARA gene mutant form results in increased expression of ITGA2 mRNA]; Tretinoin inhibits the reaction [RARA gene mutant form results in increased expression of ITGB4 mRNA]; Tretinoin inhibits the reaction [RARA gene mutant form results in increased expression of JUN mRNA]; Tretinoin inhibits the reaction [RARA gene mutant form results in increased expression of JUN protein]; Tretinoin promotes the reaction [RARA gene mutant form results in decreased expression of ITGB1 mRNA]; Tretinoin promotes the reaction [RARA gene mutant form results in decreased expression of KRT10 mRNA]; Tretinoin promotes the reaction [RARA gene mutant form results in decreased expression of KRT6 mRNA]
2-bromopalmitate inhibits the reaction [Tretinoin results in decreased expression of RARA protein]; 4-(5,6-dihydro-5,5-dimethyl-8-(quinolin-3-yl)naphthalen-2-carboxamido)benzoic acid inhibits the reaction [Tretinoin results in increased expression of RARA mRNA]; [2-bromopalmitate results in increased susceptibility to Tretinoin] which results in increased expression of RARA protein; [Decitabine co-treated with Tretinoin] results in increased expression of RARA mRNA; [Melatonin co-treated with Tretinoin] results in increased activity of RARA protein; [PCNA protein binds to RARA protein] which affects the susceptibility to Tretinoin; [RARA protein binds to RXRA protein] promotes the reaction [Tretinoin results in increased degradation of NCOA3 protein]; [RARA protein results in increased susceptibility to Tretinoin] which results in increased expression of ITGAM; [Tretinoin binds to and affects the activity of RARA protein] which results in increased activity of CDKN1A protein; [Tretinoin co-treated with Arsenic Trioxide] results in decreased expression of RARA mRNA alternative form; [Tretinoin co-treated with Butyrates] results in increased cleavage of RARA protein mutant form; [Tretinoin co-treated with caffeic acid phenethyl ester] results in increased expression of RARA mRNA; [Tretinoin co-treated with caffeic acid phenethyl ester] results in increased expression of RARA protein; [Tretinoin co-treated with hexamethylene bisacetamide] results in increased cleavage of RARA protein mutant form; [Tretinoin co-treated with RARA protein co-treated with RXRA protein] results in increased expression of CYP26A1 mRNA; [Tretinoin results in increased sumoylation of and results in decreased degradation of RARA protein] promotes the reaction [RARA protein binds to RXRA protein]; [Tretinoin results in increased ubiquitination of and results in increased degradation of RARA protein] inhibits the reaction [RARA protein binds to RXRA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in decreased expression of RARA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in increased degradation of RARA protein]; caffeic acid phenethyl ester promotes the reaction [Tretinoin results in increased activity of RARA protein]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of RARA mRNA]; IFNG protein promotes the reaction [Tretinoin results in increased expression of RARA mRNA]; Lipopolysaccharides promotes the reaction [Tretinoin results in increased expression of RARA mRNA]; Melatonin promotes the reaction [Tretinoin results in increased activity of RARA protein]; RARA gene mutant form inhibits the reaction [Tretinoin inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]]; RARA gene mutant form inhibits the reaction [Tretinoin promotes the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]]; RARA protein affects the reaction [Tretinoin results in decreased expression of CYP1A1 mRNA]; RARA protein affects the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]]; RARA protein affects the reaction [Tretinoin results in decreased secretion of IFNG protein]; RARA protein affects the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]; RARA protein affects the reaction [Tretinoin results in increased secretion of IL10 protein]; RARA protein affects the reaction [Tretinoin results in increased secretion of IL4 protein]; RARA protein promotes the reaction [Tretinoin results in increased activity of STS protein]; RARA protein promotes the reaction [Tretinoin results in increased expression of VEGFA mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of RARA mRNA]; Thiophenes analog promotes the reaction [Tretinoin results in increased expression of RARA mRNA alternative form]; Tretinoin inhibits the reaction [BTG2 protein binds to RARA protein]; Tretinoin inhibits the reaction [CCNH protein binds to and results in increased phosphorylation of RARA protein mutant form]; Tretinoin inhibits the reaction [PRMT1 protein binds to RARA protein]; Tretinoin inhibits the reaction [RARA protein mutant form results in decreased expression of SPI1 mRNA]; Tretinoin inhibits the reaction [RARA protein mutant form results in decreased expression of SPI1 protein]; Tretinoin inhibits the reaction [SIN3A protein binds to RARA protein]; Tretinoin promotes the reaction [[RARA protein binds to RXRA protein] which binds to NOS2A promoter]; Tretinoin promotes the reaction [CREBBP protein binds to RARA protein]; Tretinoin promotes the reaction [NCOA3 protein binds to RARA protein]; Tretinoin promotes the reaction [PCNA protein binds to RARA protein]; Tretinoin promotes the reaction [RARA protein binds to CD1D promoter]; Tretinoin promotes the reaction [RARA protein binds to FOLR2 promoter]; Tretinoin promotes the reaction [RARA protein binds to NCOA1 protein]; Tretinoin promotes the reaction [RARA protein binds to NCOA2 protein]; Tretinoin promotes the reaction [RARA protein binds to NCOA3 protein]; Tretinoin promotes the reaction [RARA protein binds to PRAME protein]; Tretinoin results in increased activity of [RARA protein binds to RXRA protein]; Tretinoin results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]; Tretinoin results in increased expression of and results in increased activity of RARA protein; Tretinoin results in increased sumoylation of and results in decreased degradation of RARA protein; Tretinoin results in increased ubiquitination of and results in increased degradation of RARA protein; triphenyl phosphate inhibits the reaction [Tretinoin results in increased expression of RARA mRNA]; ZNF366 protein promotes the reaction [Tretinoin results in increased activity of [RARA protein binds to RXRA protein]]