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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3534
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rara
Name: retinoic acid receptor, alpha
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Raraaffects localizationEXP 6480464CTDTretinoin affects the localization of RARA proteinPMID:17078027
Raraincreases expressionEXP 6480464CTDTretinoin results in increased expression of RARA mRNA; Tretinoin results in increased expression of RARA proteinPMID:16043492 PMID:26672737
Raramultiple interactionsEXP 6480464CTDIL1B protein promotes the reaction [Tretinoin affects the localization of RARA protein]; Tretinoin inhibits the reaction [nitrofen results in decreased expression of RARA protein]; Tretinoin inhibits the reaction [nitrofen results in increased expression of RARA protein]; Tretinoin promotes the reaction [nitrofen results in increased expression of RARA mRNA]PMID:17078027 PMID:24352370 PMID:26672737
Raraaffects bindingISORara (Mus musculus)6480464CTD[Tretinoin binds to RARA protein] which binds to NRL promoterPMID:16854989
Raraaffects bindingISORARA (Homo sapiens)6480464CTD[Tretinoin binds to [RXRA protein binds to RARA protein]] which binds to PDK4 promoter; Tretinoin binds to [RXRA protein binds to RARA protein]; Tretinoin binds to RARA proteinPMID:1318502 PMID:16757381 PMID:31195007
Raraaffects localizationISORARA (Homo sapiens)6480464CTDTretinoin affects the localization of RARA proteinPMID:16636311
Raradecreases expressionISORara (Mus musculus)6480464CTDTretinoin results in decreased expression of RARA proteinPMID:15646024
Raradecreases expressionISORARA (Homo sapiens)6480464CTDTretinoin results in decreased expression of RARA proteinPMID:15171703 PMID:15194426 PMID:15375546 PMID:16740359 PMID:24819975 PMID:30076181
Raradecreases response to substanceISORARA (Homo sapiens)6480464CTDRARA gene mutant form results in decreased susceptibility to TretinoinPMID:25003661
Raraincreases activityISORARA (Homo sapiens)6480464CTDTretinoin results in increased activity of RARA proteinPMID:16766008 PMID:25492813
Raraincreases cleavageISORARA (Homo sapiens)6480464CTDTretinoin results in increased cleavage of RARA protein mutant formPMID:12130515
Raraincreases degradationISORARA (Homo sapiens)6480464CTDTretinoin results in increased degradation of RARA protein; Tretinoin results in increased degradation of RARA protein mutant formPMID:15748426 PMID:16352814 PMID:16456540 PMID:17217047 PMID:19029980 PMID:9834237
Raraincreases expressionISORara (Mus musculus)6480464CTDTretinoin results in increased expression of RARA mRNA; Tretinoin results in increased expression of RARA proteinPMID:34464682 PMID:8892963
Raraincreases expressionISORARA (Homo sapiens)6480464CTDTretinoin results in increased expression of RARA mRNA; Tretinoin results in increased expression of RARA mRNA alternative form; Tretinoin results in increased expression of RARA proteinPMID:14592536 PMID:15171703 PMID:15703382 PMID:16007204 PMID:16140955 PMID:16636311 PMID:16766008 PMID:17034753 PMID:17138961 PMID:17216566 PMID:20507312 PMID:21393419 PMID:21934132 PMID:22906706 PMID:23724009 PMID:25725299 PMID:33167477 PMID:36805303
Raraincreases phosphorylationISORARA (Homo sapiens)6480464CTDTretinoin results in increased phosphorylation of RARA protein mutant formPMID:19029980
Raraincreases response to substanceISORARA (Homo sapiens)6480464CTDRARA protein results in increased susceptibility to TretinoinPMID:16287870 PMID:20945414 PMID:23830798 PMID:24819975
Raramultiple interactionsISORara (Mus musculus)6480464CTDRARA protein affects the reaction [Tretinoin affects the expression of CYP26A1 mRNA]; RARA protein affects the reaction [Tretinoin affects the expression of RARB mRNA]; RARA protein inhibits the reaction [Tretinoin results in increased activity of [CLOCK protein binds to BMAL1 protein]]; Tretinoin binds to and results in increased activity of RARA protein; Tretinoin inhibits the reaction [RARA gene mutant form results in decreased expression of KRT19 mRNA]; Tretinoin inhibits the reaction [RARA gene mutant form results in increased expression of ITGA2 mRNA]; Tretinoin inhibits the reaction [RARA gene mutant form results in increased expression of ITGB4 mRNA]; Tretinoin inhibits the reaction [RARA gene mutant form results in increased expression of JUN mRNA]; Tretinoin inhibits the reaction [RARA gene mutant form results in increased expression of JUN protein]; Tretinoin promotes the reaction [RARA gene mutant form results in decreased expression of ITGB1 mRNA]; Tretinoin promotes the reaction [RARA gene mutant form results in decreased expression of KRT10 mRNA]; Tretinoin promotes the reaction [RARA gene mutant form results in decreased expression of KRT6 mRNA]PMID:10748128 PMID:12504905 PMID:16261163 PMID:16839186 PMID:17069763
Raramultiple interactionsISORARA (Homo sapiens)6480464CTD2-bromopalmitate inhibits the reaction [Tretinoin results in decreased expression of RARA protein]; 4-(5,6-dihydro-5,5-dimethyl-8-(quinolin-3-yl)naphthalen-2-carboxamido)benzoic acid inhibits the reaction [Tretinoin results in increased expression of RARA mRNA]; [2-bromopalmitate results in increased susceptibility to Tretinoin] which results in increased expression of RARA protein; [Decitabine co-treated with Tretinoin] results in increased expression of RARA mRNA; [Melatonin co-treated with Tretinoin] results in increased activity of RARA protein; [PCNA protein binds to RARA protein] which affects the susceptibility to Tretinoin; [RARA protein binds to RXRA protein] promotes the reaction [Tretinoin results in increased degradation of NCOA3 protein]; [RARA protein results in increased susceptibility to Tretinoin] which results in increased expression of ITGAM; [Tretinoin binds to and affects the activity of RARA protein] which results in increased activity of CDKN1A protein; [Tretinoin co-treated with Arsenic Trioxide] results in decreased expression of RARA mRNA alternative form; [Tretinoin co-treated with Butyrates] results in increased cleavage of RARA protein mutant form; [Tretinoin co-treated with caffeic acid phenethyl ester] results in increased expression of RARA mRNA; [Tretinoin co-treated with caffeic acid phenethyl ester] results in increased expression of RARA protein; [Tretinoin co-treated with hexamethylene bisacetamide] results in increased cleavage of RARA protein mutant form; [Tretinoin co-treated with RARA protein co-treated with RXRA protein] results in increased expression of CYP26A1 mRNA; [Tretinoin results in increased sumoylation of and results in decreased degradation of RARA protein] promotes the reaction [RARA protein binds to RXRA protein]; [Tretinoin results in increased ubiquitination of and results in increased degradation of RARA protein] inhibits the reaction [RARA protein binds to RXRA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in decreased expression of RARA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in increased degradation of RARA protein]; caffeic acid phenethyl ester promotes the reaction [Tretinoin results in increased activity of RARA protein]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of RARA mRNA]; IFNG protein promotes the reaction [Tretinoin results in increased expression of RARA mRNA]; Lipopolysaccharides promotes the reaction [Tretinoin results in increased expression of RARA mRNA]; Melatonin promotes the reaction [Tretinoin results in increased activity of RARA protein]; RARA gene mutant form inhibits the reaction [Tretinoin inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]]; RARA gene mutant form inhibits the reaction [Tretinoin promotes the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]]; RARA protein affects the reaction [Tretinoin results in decreased expression of CYP1A1 mRNA]; RARA protein affects the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]]; RARA protein affects the reaction [Tretinoin results in decreased secretion of IFNG protein]; RARA protein affects the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]; RARA protein affects the reaction [Tretinoin results in increased secretion of IL10 protein]; RARA protein affects the reaction [Tretinoin results in increased secretion of IL4 protein]; RARA protein promotes the reaction [Tretinoin results in increased activity of STS protein]; RARA protein promotes the reaction [Tretinoin results in increased expression of VEGFA mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of RARA mRNA]; Thiophenes analog promotes the reaction [Tretinoin results in increased expression of RARA mRNA alternative form]; Tretinoin inhibits the reaction [BTG2 protein binds to RARA protein]; Tretinoin inhibits the reaction [CCNH protein binds to and results in increased phosphorylation of RARA protein mutant form]; Tretinoin inhibits the reaction [PRMT1 protein binds to RARA protein]; Tretinoin inhibits the reaction [RARA protein mutant form results in decreased expression of SPI1 mRNA]; Tretinoin inhibits the reaction [RARA protein mutant form results in decreased expression of SPI1 protein]; Tretinoin inhibits the reaction [SIN3A protein binds to RARA protein]; Tretinoin promotes the reaction [[RARA protein binds to RXRA protein] which binds to NOS2A promoter]; Tretinoin promotes the reaction [CREBBP protein binds to RARA protein]; Tretinoin promotes the reaction [NCOA3 protein binds to RARA protein]; Tretinoin promotes the reaction [PCNA protein binds to RARA protein]; Tretinoin promotes the reaction [RARA protein binds to CD1D promoter]; Tretinoin promotes the reaction [RARA protein binds to FOLR2 promoter]; Tretinoin promotes the reaction [RARA protein binds to NCOA1 protein]; Tretinoin promotes the reaction [RARA protein binds to NCOA2 protein]; Tretinoin promotes the reaction [RARA protein binds to NCOA3 protein]; Tretinoin promotes the reaction [RARA protein binds to PRAME protein]; Tretinoin results in increased activity of [RARA protein binds to RXRA protein]; Tretinoin results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]; Tretinoin results in increased expression of and results in increased activity of RARA protein; Tretinoin results in increased sumoylation of and results in decreased degradation of RARA protein; Tretinoin results in increased ubiquitination of and results in increased degradation of RARA protein; triphenyl phosphate inhibits the reaction [Tretinoin results in increased expression of RARA mRNA]; ZNF366 protein promotes the reaction [Tretinoin results in increased activity of [RARA protein binds to RXRA protein]]PMID:10965999 PMID:12130515 PMID:14592536 PMID:15171703 PMID:15578590 PMID:15703382 PMID:15813899 PMID:16007204 PMID:16055921 PMID:16140955 PMID:16158052 PMID:16178010 PMID:16179254 PMID:16194896 PMID:16352814 PMID:16417649 PMID:16456540 PMID:16740727 PMID:16765349 PMID:16766008 PMID:16782888 PMID:16872382 PMID:16935935 PMID:17170094 PMID:17216566 PMID:17244623 PMID:17306764 PMID:17392484 PMID:19225113 PMID:19524134 PMID:20008677 PMID:20945414 PMID:22177959 PMID:24819975 PMID:25003661 PMID:25725299 PMID:28130038 PMID:30076181
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