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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3443
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptk2
Name: protein tyrosine kinase 2
Acc ID: CHEBI:65329
Term: LY294002
Definition: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2.
Chemical ID: MESH:C085911
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptk2multiple interactionsISOPTK2 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PTK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]]PMID:16168102 PMID:26109002
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