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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3443
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptk2
Name: protein tyrosine kinase 2
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptk2affects localizationISOPTK2 (Homo sapiens)6480464CTDresveratrol affects the localization of PTK2 proteinPMID:21467134
Ptk2decreases expressionISOPTK2 (Homo sapiens)6480464CTDresveratrol results in decreased expression of PTK2 mRNA; resveratrol results in decreased expression of PTK2 proteinPMID:18089832
Ptk2decreases expressionISOPtk2 (Mus musculus)6480464CTDresveratrol results in decreased expression of PTK2 protein modified formPMID:24659233
Ptk2decreases phosphorylationISOPTK2 (Homo sapiens)6480464CTDresveratrol results in decreased phosphorylation of PTK2 proteinPMID:12421874 PMID:25605016
Ptk2increases phosphorylationISOPTK2 (Homo sapiens)6480464CTDresveratrol results in increased phosphorylation of PTK2 proteinPMID:12421874
Ptk2multiple interactionsISOPTK2 (Homo sapiens)6480464CTDresveratrol promotes the reaction [[ITGAV protein binds to ITGB3 protein] which affects the localization of PTK2 protein]PMID:21467134
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