GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ptgs1 | multiple interactions | EXP | | 6480464 | CTD | [resveratrol results in decreased activity of PTGS1 protein] which results in decreased chemical synthesis of Dinoprostone; [SC 560 results in decreased activity of PTGS1 protein] promotes the reaction [[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]]; [SC 560 results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone; Dinoprostone results in decreased susceptibility to [resveratrol results in decreased activity of PTGS1 protein] | PMID:10594344 PMID:21873648 | Ptgs1 | increases chemical synthesis | ISO | PTGS1 (Homo sapiens) | 6480464 | CTD | PTGS1 protein results in increased chemical synthesis of Dinoprostone | PMID:16894348 | Ptgs1 | multiple interactions | ISO | Ptgs1 (Mus musculus) | 6480464 | CTD | [mofezolac results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone; [resveratrol results in decreased activity of PTGS1 protein] which results in decreased chemical synthesis of Dinoprostone; [SC 560 results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone; Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CEBPA protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased degradation of and results in decreased expression of NFKBIA protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL2 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of FASL protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]] | PMID:19066340 PMID:25432964 PMID:27050768 | Ptgs1 | multiple interactions | ISO | PTGS1 (Homo sapiens) | 6480464 | CTD | Indomethacin inhibits the reaction [PTGS1 protein results in increased chemical synthesis of Dinoprostone]; PTGS1 protein promotes the reaction [IL1B protein results in increased abundance of Dinoprostone] | PMID:16354411 PMID:19751497 | | ||||||||||||||||||||||
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