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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:5855
Term: ibuprofen
Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Chemical ID: MESH:D007052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargaffects activityEXP 6480464CTDIbuprofen affects the activity of PPARG proteinPMID:25596134
Ppargincreases activityEXP 6480464CTDIbuprofen analog results in increased activity of PPARG proteinPMID:11755111
Ppargaffects activityISOPPARG (Homo sapiens)6480464CTDIbuprofen affects the activity of PPARG proteinPMID:25596134
Ppargincreases expressionISOPparg (Mus musculus)6480464CTDIbuprofen results in increased expression of PPARG mRNAPMID:16407166
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDIbuprofen binds to and results in increased activity of PPARG proteinPMID:9013583
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTDIbuprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of PPARG mRNA]; Ibuprofen inhibits the reaction [Methamphetamine results in decreased expression of PPARG protein]PMID:16407166 PMID:18946735
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