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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:33217
Term: 3,3',5,5'-tetrabromobisphenol A
Definition: A bromobisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups and the phenyl rings are substituted by bromo groups at positions 2, 2', 6 and 6'. It is a brominated flame retardant.
Chemical ID: MESH:C020806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargdecreases expressionEXP 6480464CTDtetrabromobisphenol A results in decreased expression of PPARG mRNAPMID:26988606
Ppargmultiple interactionsEXP 6480464CTDtetrabromobisphenol A inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of PPARG mRNA]PMID:25048947
Ppargaffects bindingISOPPARG (Homo sapiens)6480464CTDtetrabromobisphenol A binds to PPARG proteinPMID:25314719
Ppargdecreases expressionISOPparg (Mus musculus)6480464CTDtetrabromobisphenol A results in decreased expression of PPARG proteinPMID:24132472
Ppargincreases activityISOPPARG (Homo sapiens)6480464CTDtetrabromobisphenol A results in increased activity of PPARG proteinPMID:24591153 PMID:28282128 PMID:30138673
Ppargincreases activityISOPparg (Mus musculus)6480464CTDtetrabromobisphenol A results in increased activity of PPARG proteinPMID:25777084 PMID:25863188 PMID:30496566
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDtetrabromobisphenol A results in increased expression of PPARG mRNAPMID:32473317
Ppargincreases expressionISOPparg (Mus musculus)6480464CTDtetrabromobisphenol A results in increased expression of PPARG mRNAPMID:25863188 PMID:30496566
Ppargincreases response to substanceISOPPARG (Homo sapiens)6480464CTDPPARG protein results in increased susceptibility to tetrabromobisphenol APMID:35734227
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTD[PPARG protein results in increased susceptibility to tetrabromobisphenol A] which results in decreased expression of DHRS2 mRNA; [PPARG protein results in increased susceptibility to tetrabromobisphenol A] which results in decreased expression of FGA mRNA; [PPARG protein results in increased susceptibility to tetrabromobisphenol A] which results in decreased expression of GH1 mRNA; [PPARG protein results in increased susceptibility to tetrabromobisphenol A] which results in decreased expression of HNRNPA0 mRNA; [PPARG protein results in increased susceptibility to tetrabromobisphenol A] which results in increased expression of GDF15 mRNA; [PPARG protein results in increased susceptibility to tetrabromobisphenol A] which results in increased expression of PTMA mRNA; tetrabromobisphenol A binds to and results in increased activity of PPARG protein; tetrabromobisphenol A inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein]; tetrabromobisphenol A metabolite binds to and results in increased activity of PPARG proteinPMID:21561829 PMID:21622942 PMID:23398518 PMID:30138673 PMID:33049310 PMID:35734227
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [tetrabromobisphenol A results in decreased expression of PPARG protein]; [tetrabromobisphenol A co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA; GW 1929 inhibits the reaction [tetrabromobisphenol A results in decreased expression of PPARG protein]; tetrabromobisphenol A binds to and results in increased activity of PPARG proteinPMID:24132472 PMID:33049310 PMID:34323617
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