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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PPARG mRNA; bisphenol A results in decreased expression of PPARG proteinPMID:23399309 PMID:25181051 PMID:28772150 PMID:36835180
Ppargdecreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of PPARG genePMID:32701268
Ppargincreases expressionEXP 6480464CTDbisphenol A results in increased expression of PPARG mRNAPMID:20019905 PMID:32701268 PMID:34165232
Ppargincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of PPARG genePMID:28505145
Ppargmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with tributyltin] results in increased expression of PPARG protein; [Dietary Fats co-treated with bisphenol A] results in increased expression of PPARG mRNA; lithospermate B inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; Wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARG mRNA]PMID:23399309 PMID:25112833 PMID:31129395 PMID:34165232
Ppargaffects bindingISOPPARG (Homo sapiens)6480464CTDbisphenol A analog binds to PPARG protein; bisphenol A binds to PPARG proteinPMID:23843199 PMID:29410257 PMID:29925285
Ppargaffects expressionISOPparg (Mus musculus)6480464CTDbisphenol A affects the expression of PPARG proteinPMID:31319301
Ppargaffects methylationISOPparg (Mus musculus)6480464CTDbisphenol A affects the methylation of PPARG promoterPMID:27334623
Ppargdecreases expressionISOPPARG (Homo sapiens)6480464CTDbisphenol A results in decreased expression of PPARG mRNAPMID:28711546
Ppargdecreases expressionISOPparg (Mus musculus)6480464CTDbisphenol A results in decreased expression of PPARG mRNAPMID:30133442 PMID:34199136
Ppargdecreases methylationISOPPARG (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of PPARG genePMID:31601247
Ppargdecreases methylationISOPparg (Mus musculus)6480464CTDbisphenol A results in decreased methylation of PPARG promoterPMID:33203037
Ppargincreases activityISOPparg (Mus musculus)6480464CTDbisphenol A results in increased activity of PPARG proteinPMID:27273607
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDbisphenol A analog results in increased expression of PPARG mRNA; bisphenol A results in increased expression of PPARG mRNA; bisphenol A results in increased expression of PPARG proteinPMID:20064783 PMID:23090578 PMID:24418828 PMID:25143472 PMID:28483554 PMID:29275510 PMID:29721103 PMID:31075703 PMID:31278978 PMID:31778932 PMID:32175033 PMID:32623698 PMID:32763284 PMID:36466761 PMID:36670177
Ppargincreases expressionISOPparg (Mus musculus)6480464CTDbisphenol A results in increased expression of PPARG; bisphenol A results in increased expression of PPARG mRNA; bisphenol A results in increased expression of PPARG proteinPMID:18359623 PMID:21932408 PMID:23704952 PMID:24959901 PMID:25111128 PMID:26942597 PMID:26944108 PMID:26996129 PMID:27145005 PMID:28483554 PMID:28796629 PMID:30149043 PMID:30566610 PMID:31319301 PMID:32623698 PMID:33203037 PMID:36670177 PMID:37755785
Ppargincreases localizationISOPPARG (Homo sapiens)6480464CTDbisphenol A results in increased localization of PPARG proteinPMID:20064783
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; 4-phenylbutyric acid inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of PPARG mRNA; [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of PPARG protein; [bisphenol A results in decreased expression of MIR27B] which results in increased expression of PPARG mRNA; [Vitamin D co-treated with bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] affects the expression of PPARG mRNA; bisphenol A analog binds to and results in increased activity of PPARG protein; bisphenol A binds to and results in decreased activity of PPARG protein; bisphenol A binds to and results in increased activity of PPARG protein; bisphenol A inhibits the reaction [HNF1B protein binds to PPARG promoter]; bisphenol A inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; HNF1B protein inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; HNF1B protein inhibits the reaction [bisphenol A results in increased expression of PPARG protein]; PPARG protein affects the reaction [bisphenol A results in decreased expression of HNF1B mRNA]; PPARG protein affects the reaction [bisphenol A results in increased expression of CD36 mRNA]; PPARG protein affects the reaction [bisphenol A results in increased expression of FABP4 mRNA]; PPARG protein affects the reaction [bisphenol A results in increased expression of NR1H3 mRNA]; PPARG protein affects the reaction [bisphenol A results in increased secretion of APLN protein]; PPARG protein affects the reaction [Fulvestrant inhibits the reaction [bisphenol A inhibits the reaction [INS protein results in increased uptake of Glucose]]]; RTKI cpd inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; SREBF1 protein affects the reaction [bisphenol A results in increased expression of PPARG mRNA]; sulforaphane inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; U 0126 inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]PMID:21622942 PMID:24155963 PMID:27633901 PMID:28111160 PMID:28483554 PMID:30138673 PMID:30408883 PMID:30690568 PMID:31075703 PMID:31778932 PMID:32623698 PMID:33836827 PMID:34186270 PMID:35736896 PMID:36670177
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTD[1-Methyl-3-isobutylxanthine co-treated with bisphenol A co-treated with INS protein] results in increased expression of PPARG protein; [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] co-treated with bisphenol A] results in increased activity of PPARG protein; [bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG mRNA; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] promotes the reaction [[Dietary Sucrose co-treated with Dietary Fats] results in decreased expression of PPARG mRNA]; [bisphenol A co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] affects the expression of PPARG mRNA; [bisphenol A co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] affects the methylation of PPARG promoter; bisphenol A inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA alternative form]; bisphenol A promotes the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased activity of PPARG protein]; bisphenol A promotes the reaction [Dietary Fats results in increased expression of PPARG mRNA]; Dietary Fats promotes the reaction [bisphenol A results in increased expression of PPARG mRNA]; Dietary Fats promotes the reaction [bisphenol A results in increased expression of PPARG protein]; ginsenoside Rh1 inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; ginsenoside Rh1 inhibits the reaction [bisphenol A results in increased expression of PPARG protein]; MAP2K3 protein inhibits the reaction [MIR21A mRNA inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]]; MAP2K3 protein inhibits the reaction [MIR21A mRNA inhibits the reaction [bisphenol A results in increased expression of PPARG protein]]; Mifepristone inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; MIR21A mRNA inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; MIR21A mRNA inhibits the reaction [bisphenol A results in increased expression of PPARG protein]; sulforaphane inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; T 0070907 inhibits the reaction [[[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] co-treated with bisphenol A] results in increased activity of PPARG protein]PMID:22197818 PMID:26820058 PMID:26944108 PMID:26996129 PMID:27145005 PMID:27273607 PMID:30722647 PMID:32623698 PMID:33203037 PMID:33265944 PMID:36670177
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