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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:28837
Term: octanoic acid
Definition: A straight-chain saturated fatty acid that is heptane in which one of the hydrogens of a terminal methyl group has been replaced by a carboxy group. Octanoic acid is also known as caprylic acid.
Chemical ID: MESH:C031492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargaffects bindingEXP 6480464CTDoctanoic acid binds to PPARG proteinPMID:35752307
Ppargaffects bindingISOPPARG (Homo sapiens)6480464CTDoctanoic acid binds to PPARG proteinPMID:35752307
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTD[octanoic acid co-treated with Dexamethasone] results in increased expression of PPARG protein alternative form; [SB 203580 results in decreased activity of MAPK14 protein] inhibits the reaction [[octanoic acid co-treated with Dexamethasone] results in increased expression of PPARG protein alternative form]PMID:14984747
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