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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargdecreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of PPARG proteinPMID:30836069
Ppargincreases expressionEXP 6480464CTDDoxorubicin results in increased expression of PPARG proteinPMID:34605098
Ppargmultiple interactionsEXP 6480464CTDcaryophyllene inhibits the reaction [Doxorubicin results in decreased expression of PPARG protein]; corilagin inhibits the reaction [Doxorubicin results in increased expression of PPARG protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [Doxorubicin results in decreased expression of PPARG protein]]PMID:30836069 PMID:34605098
Ppargdecreases activityISOPPARG (Homo sapiens)6480464CTDDoxorubicin results in decreased activity of PPARG proteinPMID:25257666
Ppargdecreases expressionISOPPARG (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of PPARG mRNA; Doxorubicin results in decreased expression of PPARG proteinPMID:27417252 PMID:29803840
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTD[15-deoxyprostaglandin J2 results in increased activity of PPARG protein] which results in increased susceptibility to Doxorubicin; [nimesulide co-treated with Doxorubicin] results in increased expression of PPARGPMID:14567645 PMID:23964924
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