GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pparg | decreases expression | EXP | | 6480464 | CTD | Doxorubicin results in decreased expression of PPARG protein | PMID:30836069 | Pparg | increases expression | EXP | | 6480464 | CTD | Doxorubicin results in increased expression of PPARG protein | PMID:34605098 | Pparg | multiple interactions | EXP | | 6480464 | CTD | caryophyllene inhibits the reaction [Doxorubicin results in decreased expression of PPARG protein]; corilagin inhibits the reaction [Doxorubicin results in increased expression of PPARG protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [Doxorubicin results in decreased expression of PPARG protein]] | PMID:30836069 PMID:34605098 | Pparg | decreases activity | ISO | PPARG (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased activity of PPARG protein | PMID:25257666 | Pparg | decreases expression | ISO | PPARG (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of PPARG mRNA; Doxorubicin results in decreased expression of PPARG protein | PMID:27417252 PMID:29803840 | Pparg | multiple interactions | ISO | PPARG (Homo sapiens) | 6480464 | CTD | [15-deoxyprostaglandin J2 results in increased activity of PPARG protein] which results in increased susceptibility to Doxorubicin; [nimesulide co-treated with Doxorubicin] results in increased expression of PPARG | PMID:14567645 PMID:23964924 | |
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