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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:28499
Term: kaempferol
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment.
Chemical ID: MESH:C006552
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDkaempferol results in increased expression of PPARG mRNA; kaempferol results in increased expression of PPARG proteinPMID:25765892
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTD[kaempferol co-treated with Luteolin] inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]; dorsomorphin inhibits the reaction [[kaempferol co-treated with Luteolin] inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]]; kaempferol binds to and results in increased activity of PPARG proteinPMID:33049310 PMID:37308028
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTDkaempferol binds to and results in increased activity of PPARG protein; kaempferol inhibits the reaction [Rosiglitazone binds to and results in increased activity of PPARG protein]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]PMID:11343698 PMID:18262572 PMID:33049310
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