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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:27086
Term: tributylstannane
Definition: An organotin compound that has formula C12H28Sn.
Chemical ID: MESH:C011559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargincreases expressionEXP 6480464CTDtributyltin results in increased expression of PPARG proteinPMID:25819109 PMID:29908848 PMID:30172001 PMID:31129395
Ppargmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with tributyltin] results in increased expression of PPARG proteinPMID:31129395
Ppargaffects bindingISOPPARG (Homo sapiens)6480464CTDtributyltin binds to PPARG proteinPMID:25314719 PMID:32407875
Ppargincreases activityISOPPARG (Homo sapiens)6480464CTDtributyltin results in increased activity of PPARG proteinPMID:21622945 PMID:26172262 PMID:30138673
Ppargincreases activityISOPparg (Mus musculus)6480464CTDtributyltin results in increased activity of PPARG proteinPMID:25777084
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDtributyltin results in increased expression of PPARG mRNAPMID:26961604 PMID:29787037
Ppargincreases expressionISOPparg (Mus musculus)6480464CTDtributyltin results in increased expression of PPARG mRNA; tributyltin results in increased expression of PPARG proteinPMID:21622945 PMID:23322813 PMID:24513447 PMID:29787037 PMID:30027469 PMID:37142754
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDT 0070907 inhibits the reaction [tributyltin results in increased expression of PPARG mRNA]; tributyltin binds to and results in increased activity of PPARG protein; tributyltin inhibits the reaction [GW 1929 binds to PPARG protein]; tributyltin inhibits the reaction [Rosiglitazone binds to PPARG protein]; tributyltin inhibits the reaction [triphenyltin chloride binds to PPARG protein]PMID:19497422 PMID:24155963 PMID:24786373 PMID:29787037 PMID:31016361 PMID:33049310
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTD[triphenyltin chloride co-treated with tributyltin co-treated with dibutyldichlorotin] results in increased expression of PPARG protein; PPARG protein promotes the reaction [tributyltin binds to and results in increased activity of PPARG protein]; T 0070907 inhibits the reaction [tributyltin binds to and results in increased activity of PPARG protein]; T 0070907 inhibits the reaction [tributyltin results in increased expression of PPARG mRNA]; tributyltin binds to and results in increased activity of PPARG protein; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA alternative form]PMID:22197818 PMID:24155963 PMID:29787037 PMID:33049310 PMID:37142754
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