GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pparg | multiple interactions | ISO | PPARG (Homo sapiens) | 6480464 | CTD | 2-chloro-5-nitrobenzanilide inhibits the reaction [[[15-deoxyprostaglandin J2 results in increased activity of PPARG protein] which results in decreased expression of SOD2 protein] which results in increased abundance of Reactive Oxygen Species]; [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [troglitazone results in increased abundance of Reactive Oxygen Species]; [[15-deoxyprostaglandin J2 results in increased activity of PPARG protein] which results in decreased expression of SOD2 protein] which results in increased abundance of Reactive Oxygen Species; Acetylcysteine inhibits the reaction [[[15-deoxyprostaglandin J2 results in increased activity of PPARG protein] which results in decreased expression of SOD2 protein] which results in increased abundance of Reactive Oxygen Species]; Reactive Oxygen Species affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of PPARG protein] | PMID:16945329 PMID:22108328 PMID:23964924 | Pparg | multiple interactions | ISO | Pparg (Mus musculus) | 6480464 | CTD | [Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein; Acetylcysteine inhibits the reaction [[Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein] | PMID:22046279 | | ||||||||||||||||||||||
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