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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:18388
Term: apigenin
Definition: A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Chemical ID: MESH:D047310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargdecreases expressionISOPparg (Mus musculus)6480464CTDApigenin results in decreased expression of PPARG mRNAPMID:18359623
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDApigenin binds to and results in increased activity of PPARG proteinPMID:33049310
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTDApigenin binds to and results in increased activity of PPARG protein; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]PMID:11343698 PMID:33049310
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