GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pparg | increases expression | EXP | | 6480464 | CTD | mono-(2-ethylhexyl)phthalate results in increased expression of PPARG mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of PPARG protein | PMID:15647598 | Pparg | affects activity | ISO | PPARG (Homo sapiens) | 6480464 | CTD | mono-(2-ethylhexyl)phthalate affects the activity of PPARG protein | PMID:30810372 | Pparg | affects binding | ISO | PPARG (Homo sapiens) | 6480464 | CTD | mono-(2-ethylhexyl)phthalate binds to PPARG protein | PMID:23843199 PMID:35019730 | Pparg | affects expression | ISO | PPARG (Homo sapiens) | 6480464 | CTD | mono-(2-ethylhexyl)phthalate affects the expression of PPARG mRNA | PMID:30810372 | Pparg | decreases expression | ISO | PPARG (Homo sapiens) | 6480464 | CTD | mono-(2-ethylhexyl)phthalate results in decreased expression of PPARG mRNA; mono-(2-ethylhexyl)phthalate results in decreased expression of PPARG protein | PMID:23118965 PMID:38048874 | Pparg | decreases expression | ISO | Pparg (Mus musculus) | 6480464 | CTD | mono-(2-ethylhexyl)phthalate results in decreased expression of PPARG mRNA | PMID:25543134 | Pparg | increases activity | ISO | PPARG (Homo sapiens) | 6480464 | CTD | mono-(2-ethylhexyl)phthalate results in increased activity of PPARG protein | PMID:10581215 PMID:12927354 PMID:21561829 PMID:26172262 PMID:27551952 PMID:28282128 PMID:28571686 PMID:30138673 | Pparg | increases activity | ISO | Pparg (Mus musculus) | 6480464 | CTD | mono-(2-ethylhexyl)phthalate analog results in increased activity of PPARG protein; mono-(2-ethylhexyl)phthalate results in increased activity of PPARG protein | PMID:10581215 PMID:15322177 PMID:25777084 | Pparg | multiple interactions | ISO | PPARG (Homo sapiens) | 6480464 | CTD | 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [PPARG protein promotes the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CASP3 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [PPARG protein promotes the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CASP3 protein]]; [Diethylhexyl Phthalate results in increased abundance of mono-(2-ethylhexyl)phthalate] which results in decreased methylation of PPARG promoter; mono-(2-ethylhexyl)phthalate binds to and affects the folding of and results in increased activity of PPARG protein; mono-(2-ethylhexyl)phthalate binds to and results in increased activity of PPARG protein; PPARG mRNA promotes the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of MMP9 protein]; PPARG mRNA promotes the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of TIMP1 protein]; PPARG protein promotes the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CASP3 protein]; Rosiglitazone promotes the reaction [PPARG protein promotes the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CASP3 protein]] | PMID:12927354 PMID:16326050 PMID:28416457 PMID:30085373 PMID:33049310 PMID:37093692 | Pparg | multiple interactions | ISO | Pparg (Mus musculus) | 6480464 | CTD | [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of PPARG mRNA; mono-(2-ethylhexyl)phthalate binds to and results in increased activity of PPARG protein | PMID:31884101 PMID:33049310 | | ||||||||||||||||||||||
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