GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pparg | decreases expression | EXP | | 6480464 | CTD | Glucose results in decreased expression of PPARG mRNA; Glucose results in decreased expression of PPARG protein | PMID:19609456 PMID:31063766 | Pparg | multiple interactions | EXP | | 6480464 | CTD | [ciglitazone binds to and results in increased activity of PPARG protein] which results in increased transport of Glucose; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PPARG mRNA; HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARG protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARG protein]; PPARG protein inhibits the reaction [Glucose results in increased secretion of INS1 protein]; tetrahydropalmatine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PPARG mRNA] | PMID:15878969 PMID:18063688 PMID:31063766 PMID:37606869 | Pparg | decreases expression | ISO | PPARG (Homo sapiens) | 6480464 | CTD | Glucose results in decreased expression of PPARG protein | PMID:21333731 | Pparg | multiple interactions | ISO | PPARG (Homo sapiens) | 6480464 | CTD | 2-chloro-5-nitrobenzanilide inhibits the reaction [Rosiglitazone inhibits the reaction [Glucose results in decreased expression of PPARG protein]]; [Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of PPARG mRNA; avobenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; dioxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; PPARG protein affects the reaction [Fulvestrant inhibits the reaction [bisphenol A inhibits the reaction [INS protein results in increased uptake of Glucose]]]; Rosiglitazone inhibits the reaction [Glucose results in decreased expression of PPARG protein] | PMID:21333731 PMID:32407875 PMID:32613381 PMID:32623698 | | ||||||||||||||||||||||
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