GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pparg | decreases expression | EXP | | 6480464 | CTD | Oxygen results in decreased expression of PPARG mRNA; Oxygen results in decreased expression of PPARG protein | PMID:16617452 | Pparg | multiple interactions | EXP | | 6480464 | CTD | 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARG protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Rosiglitazone inhibits the reaction [Oxygen results in decreased expression of PPARG mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Rosiglitazone inhibits the reaction [Oxygen results in decreased expression of PPARG protein]]; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARG protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PPARG mRNA; Mifepristone inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARG protein]; Rosiglitazone inhibits the reaction [Oxygen results in decreased expression of PPARG mRNA]; Rosiglitazone inhibits the reaction [Oxygen results in decreased expression of PPARG protein]; tetrahydropalmatine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PPARG mRNA]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARG protein] | PMID:16617452 PMID:27274199 PMID:30229846 PMID:37606869 | Pparg | affects activity | ISO | PPARG (Homo sapiens) | 6480464 | CTD | Oxygen deficiency affects the activity of PPARG protein | PMID:25596134 | Pparg | affects expression | ISO | Pparg (Mus musculus) | 6480464 | CTD | Oxygen deficiency affects the expression of PPARG protein | PMID:28859903 | Pparg | decreases expression | ISO | PPARG (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in decreased expression of PPARG protein | PMID:19520921 | Pparg | decreases expression | ISO | Pparg (Mus musculus) | 6480464 | CTD | Oxygen deficiency results in decreased expression of PPARG mRNA; Oxygen deficiency results in decreased expression of PPARG protein | PMID:21531777 | Pparg | increases expression | ISO | PPARG (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased expression of PPARG mRNA | PMID:26516004 | Pparg | increases expression | ISO | Pparg (Mus musculus) | 6480464 | CTD | Oxygen deficiency results in increased expression of PPARG protein; Oxygen results in increased expression of PPARG mRNA | PMID:21113404 PMID:22535284 | Pparg | multiple interactions | ISO | PPARG (Homo sapiens) | 6480464 | CTD | [Oxygen deficiency co-treated with Oxygen] results in decreased expression of PPARG mRNA; [Oxygen deficiency co-treated with Oxygen] results in decreased expression of PPARG protein; ALKBH5 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of PPARG protein]; PPARG protein inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of ALCAM protein]; PPARG protein inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of VIM protein]; PPARG protein inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of CDH1 protein]; PPARG protein inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of ENG protein] | PMID:34995009 | Pparg | multiple interactions | ISO | Pparg (Mus musculus) | 6480464 | CTD | [Dexamethasone co-treated with Oxygen deficiency] results in increased expression of PPARG mRNA alternative form; [Resveratrol co-treated with Oxygen deficiency] results in increased expression of PPARG protein; bazedoxifene affects the reaction [Oxygen deficiency affects the expression of PPARG protein]; Rosiglitazone inhibits the reaction [Oxygen deficiency results in decreased expression of PPARG mRNA]; Rosiglitazone inhibits the reaction [Oxygen deficiency results in decreased expression of PPARG protein] | PMID:16814746 PMID:21113404 PMID:21531777 PMID:28859903 | | ||||||||||||||||||||||
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