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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3322 Species: Rattus norvegicus RGD Object: Gene Symbol: Phb Name: prohibitin

Acc ID: CHEBI:4903 Term: 17alpha-ethynylestradiol Definition: A 17-hydroxy steroid that has formula C20H24O2. CasRN: 57-63-6 Chemical ID: MESH:D004997

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:11096	6480464	CTD	Ethinyl Estradiol results in increased expression of PHB mRNA	PMID:17942748 PMID:16174780 PMID:17555576
multiple interactions	ISO	RGD:11096	6480464	CTD	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHB mRNA	PMID:17942748
increases expression	EXP		6480464	CTD	Ethinyl Estradiol results in increased expression of PHB mRNA	PMID:16174780
increases expression	ISO	RGD:11096	6480464	CTD	Ethinyl Estradiol results in increased expression of PHB mRNA	PMID:17555576 PMID:16174780 PMID:17942748
increases expression	ISO	RGD:11096	6480464	CTD	Ethinyl Estradiol results in increased expression of PHB mRNA	PMID:16174780 PMID:17555576 PMID:17942748
increases expression	ISO	RGD:11096	6480464	CTD	Ethinyl Estradiol results in increased expression of PHB mRNA	PMID:16174780 PMID:17942748 PMID:17555576