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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:88212
Term: lead(II) chloride
Definition: An inorganic chloride consisting of two chlorine atoms covalently bound to a central lead atom.
Chemical ID: MESH:C029891
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgrincreases expressionISOPGR (Homo sapiens)6480464CTDlead chloride results in increased expression of PGR mRNA; lead chloride results in increased expression of PGR proteinPMID:12746304
Pgrmultiple interactionsISOPGR (Homo sapiens)6480464CTDEstradiol promotes the reaction [lead chloride results in increased expression of PGR mRNA]; Estradiol promotes the reaction [lead chloride results in increased expression of PGR protein]; fulvestrant inhibits the reaction [lead chloride results in increased expression of PGR mRNA]; fulvestrant inhibits the reaction [lead chloride results in increased expression of PGR protein]; lead chloride promotes the reaction [Estradiol results in increased expression of PGR mRNA]; lead chloride promotes the reaction [Estradiol results in increased expression of PGR protein]PMID:12746304
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