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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:76591
Term: (25R)-cholest-5-ene-3beta,26-diol
Definition: A 26-hydroxycholesterol in which the 25-position has R-configuration.
Chemical ID: MESH:C076996
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgrincreases expressionISOPGR (Homo sapiens)6480464CTD27-hydroxycholesterol results in increased expression of PGR mRNA; 27-hydroxycholesterol results in increased expression of PGR proteinPMID:17872378
Pgrmultiple interactionsISOPGR (Homo sapiens)6480464CTDfulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of PGR mRNA]PMID:17872378
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