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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgrincreases expressionISOPGR (Homo sapiens)6480464CTDDecitabine results in increased expression of PGR mRNA; Decitabine results in increased expression of PGR mRNA alternative form; Decitabine results in increased expression of PGR protein alternative formPMID:16024066 PMID:21515334
Pgrmultiple interactionsISOPGR (Homo sapiens)6480464CTD[Decitabine co-treated with trichostatin A] affects the expression of PGR mRNA; [Decitabine co-treated with trichostatin A] results in increased expression of PGR mRNA; [trichostatin A co-treated with Decitabine] results in increased expression of PGR mRNA alternative form; [trichostatin A co-treated with Decitabine] results in increased expression of PGR protein alternative form; Decitabine inhibits the reaction [Promegestone results in increased activity of PGR protein]PMID:16024066 PMID:17533736 PMID:18264725 PMID:30818834
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