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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:17263
Term: estrone
Definition: A 17-oxo steroid that is estra-1,3,5(10)-triene substituted by an hydroxy group at position 3 and an oxo group at position 17.
Chemical ID: MESH:D004970
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgrdecreases expressionISOPGR (Homo sapiens)6480464CTDEstrone results in decreased expression of PGR mRNA alternative form; Estrone results in decreased expression of PGR protein alternative formPMID:15806153
Pgrincreases expressionISOPGR (Homo sapiens)6480464CTDEstrone results in increased expression of PGR mRNAPMID:26865669
Pgrmultiple interactionsISOPGR (Homo sapiens)6480464CTDfulvestrant inhibits the reaction [Estrone results in decreased expression of PGR protein alternative form]PMID:15806153
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