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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3227
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Odc1
Name: ornithine decarboxylase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Odc1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of ODC1 mRNAPMID:32109520 PMID:34747641
Odc1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of ODC1 mRNAPMID:33387578
Odc1affects expressionISOOdc1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of ODC1 mRNAPMID:21570461
Odc1decreases expressionISOODC1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ODC1 mRNAPMID:12377990 PMID:20106945 PMID:21632981
Odc1increases expressionISOOdc1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ODC1 mRNAPMID:16467188 PMID:17586704 PMID:17942748
Odc1increases expressionISOODC1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of ODC1 mRNAPMID:18061397 PMID:23152189
Odc1multiple interactionsISOOdc1 (Mus musculus)6480464CTD[NFE2L2 gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of ODC1 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ODC1 mRNAPMID:17942748 PMID:21846477
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