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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3227
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Odc1
Name: ornithine decarboxylase 1
Acc ID: CHEBI:15746
Term: spermine
Definition: A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism.
Chemical ID: MESH:D013096
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Odc1multiple interactionsEXP 6480464CTD[[Ornithine Decarboxylase Inhibitors results in decreased activity of ODC1 protein] which results in decreased chemical synthesis of Polyamines] which results in decreased abundance of Spermine; [ODC1 protein results in increased chemical synthesis of Polyamines] which results in increased abundance of Spermine; [Pentanoic Acids results in decreased activity of ODC1 protein] which results in decreased abundance of SperminePMID:20805360 PMID:22555848
Odc1increases abundanceISOOdc1 (Mus musculus)6480464CTDODC1 protein results in increased abundance of SperminePMID:22555848
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