GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Slc22a1 | decreases expression | EXP | | 6480464 | CTD | 1-Methyl-4-phenylpyridinium results in decreased expression of SLC22A1 mRNA | PMID:28801915 | Slc22a1 | increases uptake | EXP | | 6480464 | CTD | SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium | PMID:16142924 | Slc22a1 | multiple interactions | EXP | | 6480464 | CTD | 1-Methyl-4-phenylpyridinium affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; tetrabutylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; tetrapentylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | PMID:12440152 PMID:16142924 | Slc22a1 | increases import | ISO | SLC22A1 (Homo sapiens) | 6480464 | CTD | SLC22A1 protein results in increased import of 1-Methyl-4-phenylpyridinium; SLC22A1 results in increased import of 1-Methyl-4-phenylpyridinium | PMID:22394605 PMID:9260930 | Slc22a1 | increases transport | ISO | SLC22A1 (Homo sapiens) | 6480464 | CTD | SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium | PMID:16263091 PMID:25466967 | Slc22a1 | increases uptake | ISO | SLC22A1 (Homo sapiens) | 6480464 | CTD | SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium | PMID:11388889 PMID:12110607 PMID:16141367 PMID:23831208 PMID:27504015 PMID:28867436 PMID:32003934 | Slc22a1 | multiple interactions | ISO | SLC22A1 (Homo sapiens) | 6480464 | CTD | 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; [MYC protein results in increased expression of SLC22A1 protein] which results in increased import of 1-Methyl-4-phenylpyridinium; Amiodarone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; artemisinin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Atenolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Atorvastatin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Bisoprolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Carvedilol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Chloroquine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Digoxin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Diltiazem inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; diosmetin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Diphenhydramine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Estradiol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Etilefrine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Famotidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Flecainide inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Ipratropium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Lidocaine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Mefloquine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Metformin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Metoprolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Molsidomine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Monocrotaline inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Nadolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Nifedipine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Phenoxybenzamine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Prazosin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Progesterone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Propafenone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Propranolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; pseudoisocyanine affects the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; pseudoisocyanine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Pyrimethamine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Spironolactone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; talinolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | PMID:11388889 PMID:12110607 PMID:16141367 PMID:16263091 PMID:19239227 PMID:19357179 PMID:21641380 PMID:23831208 PMID:25466967 PMID:27504015 PMID:28867436 PMID:32003934 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |