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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3224
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a1
Name: solute carrier family 22 member 1
Acc ID: CHEBI:28593
Term: quinidine
Definition: A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.
Chemical ID: MESH:D011802
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a1multiple interactionsEXP 6480464CTD[Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine; [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of SynephrinePMID:21140131
Slc22a1multiple interactionsISOSLC22A1 (Homo sapiens)6480464CTDQuinidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]PMID:16141367 PMID:23831208 PMID:24799337 PMID:24947867
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