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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3224
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a1
Name: solute carrier family 22 member 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a1multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]PMID:19605544
Slc22a1increases uptakeISOSLC22A1 (Homo sapiens)6480464CTDSLC22A1 protein results in increased uptake of QuercetinPMID:24947867
Slc22a1multiple interactionsISOSLC22A1 (Homo sapiens)6480464CTDImipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]; Trimethoprim inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]PMID:24947867
Slc22a1multiple interactionsISOSlc22a1 (Mus musculus)6480464CTDQuercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]; Quercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]PMID:21909718
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