GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nppa | increases expression | EXP | | 11526363 | RGD | phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes | | Nppa | decreases response to substance | EXP | | 6480464 | CTD | NPPA protein results in decreased susceptibility to Phenylephrine | PMID:8188982 | Nppa | increases expression | EXP | | 6480464 | CTD | Phenylephrine results in increased expression of NPPA mRNA; Phenylephrine results in increased expression of NPPA protein | PMID:10642269 PMID:10655507 PMID:10727428 PMID:10843871 PMID:10888249 PMID:11042672 PMID:11230109 PMID:11470465 PMID:11754973 PMID:11799083 PMID:11799084 PMID:11836006 PMID:11854500 PMID:12435817 PMID:12682052 PMID:14718400 PMID:15191894 PMID:15220332 PMID:15258898 PMID:15452191 PMID:15522277 PMID:15721863 PMID:15795322 PMID:16170337 PMID:16421291 PMID:16513848 PMID:16517124 PMID:16533503 PMID:16556869 PMID:16787574 PMID:16809552 PMID:17124262 PMID:17204550 PMID:17266992 PMID:17287366 PMID:17327491 PMID:17499311 PMID:17592507 PMID:18252717 PMID:18378355 PMID:18701451 PMID:18790048 PMID:18851973 PMID:19111554 PMID:19540241 PMID:19729022 PMID:19966059 PMID:19966502 PMID:20886221 PMID:21565836 PMID:23297412 PMID:23939492 PMID:25341891 PMID:25358972 PMID:25449040 PMID:27094368 PMID:27094369 PMID:28759639 PMID:28822817 | Nppa | increases secretion | EXP | | 6480464 | CTD | Phenylephrine results in increased secretion of NPPA protein | PMID:10642269 PMID:11754973 PMID:12435817 PMID:12729799 PMID:20067472 | Nppa | multiple interactions | EXP | | 6480464 | CTD | (+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; (+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 2-Chloroadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-trifluoromethylsalicylic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 8-(3-chlorostyryl)caffeine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 8-(4-sulfophenyl)theophylline inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [Phenylephrine co-treated with Oxygen deficiency] results in increased expression of NPPA mRNA; [Phenylephrine results in increased activity of CREBBP protein] which results in increased expression of NPPA protein; [Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA protein; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA3 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Aldosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; BQ 788 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Caffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; CEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPA protein]; chelerythrine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; chelerythrine promotes the reaction [2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Corticosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CREBBP protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine affects the expression of NPPA protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Fulvestrant inhibits the reaction [[Estradiol co-treated with Phenylephrine] results in increased expression of NPPA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPA protein]; IKBKB protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ILK protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; KCND2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; kenpaullone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; leptomycin B inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MBF1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; MEKK1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Metoprolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N(6)-phenyl-cAMP analog inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; NFKBIA protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [BRD4 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [CTNNB1 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [MYOCD protein binds to NPPA promoter]; polydatin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Propranolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]; Resveratrol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RHOA protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SK-7041 inhibits the reaction [Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]]; SK-7041 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; trichostatin A inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; triflusal inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; U 0126 inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; xestospongin C inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] | PMID:10642269 PMID:10655507 PMID:10727428 PMID:10843871 PMID:10888249 PMID:11042672 PMID:11381115 PMID:11470465 PMID:11513749 PMID:11705990 PMID:11739382 PMID:11799083 PMID:11799084 PMID:11854500 PMID:12403671 PMID:12477714 PMID:12513686 PMID:12729799 PMID:14676212 PMID:14718400 PMID:15007106 PMID:15220332 PMID:15258898 PMID:15452191 PMID:15721863 PMID:16170337 PMID:16421291 PMID:16513848 PMID:16517124 PMID:16533503 PMID:16556869 PMID:16787574 PMID:16809552 PMID:17266992 PMID:17327491 PMID:17592507 PMID:18701451 PMID:18790048 PMID:18851973 PMID:19540241 PMID:19729022 PMID:19799869 PMID:19966059 PMID:19966502 PMID:20067472 PMID:20886221 PMID:21565836 PMID:23297412 PMID:23939492 PMID:25341891 PMID:25449040 PMID:27094368 PMID:27094369 PMID:28759639 | Nppa | increases expression | ISO | Nppa (Mus musculus) | 6480464 | CTD | Phenylephrine results in increased expression of NPPA mRNA; Phenylephrine results in increased expression of NPPA protein | PMID:10679475 PMID:11299230 PMID:11804996 PMID:16380548 PMID:16603706 PMID:16690042 PMID:18487437 PMID:18502941 | Nppa | increases secretion | ISO | NPPA (Homo sapiens) | 6480464 | CTD | Phenylephrine results in increased secretion of NPPA protein | PMID:2847676 | Nppa | multiple interactions | ISO | Nppa (Mus musculus) | 6480464 | CTD | [NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of NPPA mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; DGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUND protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA] | PMID:10710348 PMID:11499749 PMID:12754203 PMID:15201137 PMID:15939815 PMID:16380548 PMID:16603706 PMID:16690042 PMID:18502941 | | ||||||||||||||||||||||
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