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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3193
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nppa
Name: natriuretic peptide A
Acc ID: CHEBI:3441
Term: carvedilol
Definition: A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.
Chemical ID: MESH:C043211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nppadecreases degradationEXP 6480464CTDcarvedilol results in decreased degradation of NPPA proteinPMID:9421401
Nppadecreases expressionEXP 6480464CTDcarvedilol results in decreased expression of NPPA mRNAPMID:21216836
Nppaincreases expressionEXP 6480464CTDcarvedilol results in increased expression of NPPA mRNA; carvedilol results in increased expression of NPPA proteinPMID:11206715 PMID:9421401
Nppamultiple interactionsEXP 6480464CTDcarvedilol inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; carvedilol promotes the reaction [NPPA protein results in increased abundance of Cyclic GMP]PMID:10722803 PMID:9421401
Nppadecreases expressionISONPPA (Homo sapiens)6480464CTDcarvedilol results in decreased expression of NPPA proteinPMID:1378157
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