GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Notch1 | decreases activity | ISO | NOTCH1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased activity of NOTCH1 protein | PMID:23542114 | Notch1 | decreases expression | ISO | NOTCH1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of NOTCH1; Arsenic Trioxide results in decreased expression of NOTCH1 mRNA; Arsenic Trioxide results in decreased expression of NOTCH1 protein | PMID:22949821 PMID:22978106 PMID:23497375 PMID:24801890 PMID:25088040 PMID:33634982 | Notch1 | decreases response to substance | ISO | NOTCH1 (Homo sapiens) | 6480464 | CTD | NOTCH1 protein results in decreased susceptibility to Arsenic Trioxide | PMID:22949821 | Notch1 | increases expression | ISO | NOTCH1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of NOTCH1 mRNA; Arsenic Trioxide results in increased expression of NOTCH1 protein | PMID:29738779 | Notch1 | multiple interactions | ISO | NOTCH1 (Homo sapiens) | 6480464 | CTD | 4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline inhibits the reaction [Arsenic Trioxide results in decreased expression of NOTCH1 protein]; [Arsenic Trioxide results in decreased activity of NOTCH1 protein] which results in decreased phosphorylation of and results in decreased activity of STAT3 protein; Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of NOTCH1 protein]; Arsenic Trioxide inhibits the reaction [PROM1 protein results in increased activity of NOTCH1 protein]; Arsenic Trioxide results in decreased expression of and results in increased phosphorylation of NOTCH1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arsenic Trioxide results in decreased expression of NOTCH1 protein]; BI 2536 inhibits the reaction [Arsenic Trioxide results in decreased expression of NOTCH1 protein]; RO3280 inhibits the reaction [Arsenic Trioxide results in decreased expression of NOTCH1 protein] | PMID:23542114 PMID:23832679 PMID:24801890 PMID:31307525 PMID:31597699 | | ||||||||||||||||||||||
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