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GENE - TERM ANNOTATION REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: DOID:10763
Term: hypertension
Definition: An artery disease characterized by chronic elevated blood pressure in the arteries. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Hypertension "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/24352797 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3 IDA 1580271RGD  
Nos3treatmentIDA 13504683RGD  
Nos3 IEP 2292113RGDassociated with Pregnancy Complications 
Nos3 IEP 4891993RGDprotein:decreased phosphorylation:brain 
Nos3treatmentIEP 13446414RGD  
Nos3treatmentIEP 401793758RGD  
Nos3 ISONOS3 (Homo sapiens)1580282RGDDNA:snp:cds:p.E298D (human) 
Nos3no_associationISONOS3 (Homo sapiens)1580278RGDDNA:duplication, snp:intron, cds:IVS4?-?+27, p.E298D (human) 
Nos3 ISONOS3 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanism|therapeuticPMID:11457755 PMID:12947532 PMID:16331104 PMID:19008412 PMID:19407804
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