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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3affects response to substanceEXP 6480464CTDNOS3 protein affects the susceptibility to PhenylephrinePMID:11504159
Nos3decreases response to substanceEXP 6480464CTDNOS3 protein results in decreased susceptibility to PhenylephrinePMID:10954898
Nos3increases expressionEXP 6480464CTDPhenylephrine results in increased expression of NOS3 mRNA; Phenylephrine results in increased expression of NOS3 proteinPMID:15753950
Nos3multiple interactionsEXP 6480464CTDNOS3 protein results in increased susceptibility to [Acetylcholine co-treated with Phenylephrine]PMID:10954898
Nos3affects response to substanceISONos3 (Mus musculus)6480464CTDNOS3 protein affects the susceptibility to PhenylephrinePMID:17403420
Nos3decreases response to substanceISONos3 (Mus musculus)6480464CTDNOS3 protein results in decreased susceptibility to PhenylephrinePMID:15381055
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