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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:6980
Term: monocrotaline
Definition: A pyrrolizidine alkaloid that has formula C16H23NO6.
Chemical ID: MESH:D016686
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3decreases activityEXP 6480464CTDMonocrotaline results in decreased activity of NOS3 proteinPMID:16225752
Nos3decreases expressionEXP 6480464CTDMonocrotaline results in decreased expression of NOS3 mRNA; Monocrotaline results in decreased expression of NOS3 proteinPMID:25460361 PMID:30466619
Nos3increases expressionEXP 6480464CTDMonocrotaline results in increased expression of NOS3 mRNAPMID:16225752 PMID:22022327
Nos3multiple interactionsEXP 6480464CTD4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in decreased activity of NOS3 protein]; 4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of NOS3 mRNA]; magnolol inhibits the reaction [Monocrotaline results in decreased expression of NOS3 protein]; Quercetin inhibits the reaction [Monocrotaline results in decreased expression of NOS3 mRNA]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of NOS3 mRNA]PMID:16225752 PMID:22022327 PMID:25460361 PMID:30466619
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