GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nos3 | increases expression | EXP | | 6480464 | CTD | Sildenafil Citrate results in increased expression of NOS3 protein | PMID:19845545 | Nos3 | increases phosphorylation | EXP | | 6480464 | CTD | Sildenafil Citrate results in increased phosphorylation of NOS3 protein | PMID:18373738 | Nos3 | multiple interactions | EXP | | 6480464 | CTD | [Cisplatin co-treated with Sildenafil Citrate] results in increased expression of NOS3 mRNA; [Cisplatin co-treated with Sildenafil Citrate] results in increased expression of NOS3 protein; [Sildenafil Citrate co-treated with Resveratrol] inhibits the reaction [Streptozocin results in decreased expression of NOS3 protein]; [Sildenafil Citrate results in increased expression of NOS3 protein] which results in increased secretion of Nitric Oxide; Sildenafil Citrate inhibits the reaction [alpha-naphthyl thiourea results in decreased expression of NOS3 mRNA]; Sildenafil Citrate inhibits the reaction [alpha-naphthyl thiourea results in decreased expression of NOS3 protein]; Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein] | PMID:19152827 PMID:19845545 PMID:26006044 PMID:30974023 PMID:32479886 | Nos3 | increases activity | ISO | Nos3 (Mus musculus) | 6480464 | CTD | Sildenafil Citrate results in increased activity of NOS3 protein | PMID:23650378 | | ||||||||||||||||||||||
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