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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:3441
Term: carvedilol
Definition: A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.
Chemical ID: MESH:C043211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3decreases expressionEXP 6480464CTDcarvedilol results in decreased expression of NOS3 mRNAPMID:16741616
Nos3increases expressionEXP 6480464CTDcarvedilol results in increased expression of NOS3 mRNA; carvedilol results in increased expression of NOS3 proteinPMID:17559835 PMID:18971572
Nos3increases phosphorylationEXP 6480464CTDcarvedilol results in increased phosphorylation of NOS3 proteinPMID:17559835
Nos3multiple interactionsISONOS3 (Homo sapiens)6480464CTDCarvedilol inhibits the reaction [Doxorubicin results in decreased phosphorylation of NOS3 protein]PMID:31066085
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