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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:33234
Term: vitamin E
Definition: Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.
Chemical ID: MESH:D024502
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3multiple interactionsEXP 6480464CTD[Vitamin E co-treated with Ascorbic Acid] inhibits the reaction [Dexamethasone results in decreased expression of NOS3 protein]; Vitamin E inhibits the reaction [Lead results in increased expression of NOS3 protein]PMID:10523326 PMID:20068362
Nos3decreases expressionISONos3 (Mus musculus)6480464CTDVitamin E results in decreased expression of NOS3 proteinPMID:11597945
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