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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3decreases expressionEXP 6480464CTDfulvestrant results in decreased expression of NOS3 proteinPMID:19962728
Nos3multiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [Estradiol results in increased expression of NOS3 protein]PMID:11583108
Nos3multiple interactionsISONOS3 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of NOS3 gene; [Fulvestrant co-treated with MK-886] inhibits the reaction [Resveratrol results in increased expression of NOS3 mRNA]; Fulvestrant inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased expression of NOS3 mRNA]; Fulvestrant inhibits the reaction [[Estradiol co-treated with ESR2 protein] results in increased expression of NOS3 mRNA]; Fulvestrant inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; Fulvestrant inhibits the reaction [amurensin G results in increased phosphorylation of NOS3 protein]; Fulvestrant inhibits the reaction [Dibutyl Phthalate results in increased phosphorylation of NOS3 protein]; Fulvestrant inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]PMID:14742696 PMID:21791144 PMID:21884717 PMID:22982565 PMID:31601247 PMID:36089060
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