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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:27496
Term: simazine
Definition: A diamino-1,3,5-triazine that is N,N'-diethyl-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.
Chemical ID: MESH:D012839
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3decreases expressionISONos3 (Mus musculus)6480464CTDSimazine results in decreased expression of NOS3 mRNA; Simazine results in decreased expression of NOS3 proteinPMID:22984576 PMID:27431321
Nos3decreases expressionISONOS3 (Homo sapiens)6480464CTDSimazine results in decreased expression of NOS3 mRNA; Simazine results in decreased expression of NOS3 proteinPMID:27431321
Nos3multiple interactionsISONOS3 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of NOS3 protein]; U 0126 inhibits the reaction [Simazine results in decreased expression of NOS3 protein]PMID:27431321
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