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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186 Species: Rattus norvegicus RGD Object: Gene Symbol: Nos3 Name: nitric oxide synthase 3, endothelial cell

Acc ID: CHEBI:17703 Term: 26-hydroxycholesterol Definition: An oxysterol that has formula C27H46O2. CasRN: 20380-11-4 Chemical ID: MESH:C076996

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:10997	6480464	CTD	27-hydroxycholesterol inhibits the reaction [Estradiol results in increased expression of NOS3 mRNA] ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA] ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]	PMID:17873880
decreases expression	ISO	RGD:10997	6480464	CTD	27-hydroxycholesterol results in decreased expression of NOS3 mRNA	PMID:17873880