GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nos3 | decreases activity | ISO | NOS3 (Homo sapiens) | 6480464 | CTD | Hydrogen Peroxide results in decreased activity of NOS3 protein | PMID:22358095 PMID:23639522 | Nos3 | decreases expression | ISO | NOS3 (Homo sapiens) | 6480464 | CTD | Hydrogen Peroxide results in decreased expression of NOS3 mRNA; Hydrogen Peroxide results in decreased expression of NOS3 protein | PMID:19105596 PMID:20562903 PMID:22902249 PMID:23859249 PMID:31586451 | Nos3 | increases expression | ISO | NOS3 (Homo sapiens) | 6480464 | CTD | Hydrogen Peroxide results in increased expression of NOS3 mRNA; Hydrogen Peroxide results in increased expression of NOS3 protein | PMID:14607919 PMID:18234130 PMID:20021702 | Nos3 | multiple interactions | ISO | NOS3 (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [anagliptin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; [Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein; [Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein; [Hydrogen Peroxide results in decreased activity of NOS3 protein] which results in decreased chemical synthesis of Nitric Oxide; [Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide; anagliptin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]; anagliptin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]; catalase-polyethylene glycol inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]; epigallocatechin gallate promotes the reaction [Hydrogen Peroxide results in increased expression of NOS3 mRNA]; Genistein inhibits the reaction [Hydrogen Peroxide results in increased expression of NOS3 mRNA]; Hydrogen Peroxide inhibits the reaction [SP1 protein binds to NOS3 promoter]; myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased activity of NOS3 protein]; Nifedipine inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]; Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]; Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]; Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]; Nifedipine promotes the reaction [Simvastatin inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; Phloretin inhibits the reaction [Hydrogen Peroxide results in increased expression of NOS3 mRNA]; Phlorhizin inhibits the reaction [Hydrogen Peroxide results in increased expression of NOS3 mRNA]; Plant Extracts inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]; Resveratrol inhibits the reaction [[Hydrogen Peroxide results in decreased activity of NOS3 protein] which results in decreased chemical synthesis of Nitric Oxide]; Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]; Resveratrol promotes the reaction [Hydrogen Peroxide results in increased expression of NOS3 mRNA]; Simvastatin inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]; Simvastatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]; Simvastatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]; Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]]; Stilbenes inhibits the reaction [[Hydrogen Peroxide results in decreased activity of NOS3 protein] which results in decreased chemical synthesis of Nitric Oxide]; Wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; Wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]] | PMID:18234130 PMID:19105596 PMID:20021702 PMID:20562903 PMID:22358095 PMID:22902249 PMID:23639522 PMID:23859249 PMID:31586451 | | ||||||||||||||||||||||
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