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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3183
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nog
Name: noggin
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nogmultiple interactionsEXP 6480464CTDNOG protein promotes the reaction [GH1 protein promotes the reaction [FSHB protein results in increased abundance of Progesterone]]PMID:22067323
Nogmultiple interactionsISONog (Mus musculus)6480464CTDNOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]PMID:23137853
Nogmultiple interactionsISONOG (Homo sapiens)6480464CTDNOG protein inhibits the reaction [BMP2 protein results in decreased abundance of Progesterone]; Progesterone promotes the reaction [Estradiol results in increased expression of NOG mRNA]PMID:20639315 PMID:21795739
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