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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3181
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nmbr
Name: neuromedin B receptor
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nmbrincreases expressionISONMBR (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of NMBR mRNA; Oxygen deficiency results in increased expression of NMBR proteinPMID:24349381
Nmbrmultiple interactionsISONMBR (Homo sapiens)6480464CTD3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Oxygen deficiency results in increased expression of NMBR mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Oxygen deficiency results in increased expression of NMBR protein]; Oxygen deficiency promotes the reaction [[HIF1A protein binds to NMBR promoter] which results in increased expression of NMBR mRNA]; Oxygen deficiency promotes the reaction [HIF1A protein binds to NMBR promoter]PMID:24349381
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