GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcc1 | affects response to substance | ISO | ABCC1 (Homo sapiens) | 6480464 | CTD | ABCC1 protein affects the susceptibility to Etoposide | PMID:16217747 PMID:9334814 | Abcc1 | decreases response to substance | ISO | Abcc1 (Mus musculus) | 6480464 | CTD | ABCC1 protein results in decreased susceptibility to Etoposide; ABCC1 results in decreased susceptibility to Etoposide | PMID:10856430 PMID:8968083 | Abcc1 | decreases response to substance | ISO | ABCC1 (Homo sapiens) | 6480464 | CTD | ABCC1 protein results in decreased susceptibility to Etoposide; ABCC1 results in decreased susceptibility to Etoposide | PMID:10900222 PMID:11778547 PMID:15180633 PMID:15460906 PMID:15999103 PMID:16156793 PMID:7954421 | Abcc1 | decreases uptake | ISO | Abcc1 (Mus musculus) | 6480464 | CTD | ABCC1 protein results in decreased uptake of Etoposide | PMID:10856430 | Abcc1 | increases expression | ISO | Abcc1 (Mus musculus) | 6480464 | CTD | Etoposide results in increased expression of ABCC1 mRNA | PMID:10856430 | Abcc1 | multiple interactions | ISO | Abcc1 (Mus musculus) | 6480464 | CTD | Glucose inhibits the reaction [Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]]; Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]; Verapamil inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide] | PMID:10856430 | Abcc1 | multiple interactions | ISO | ABCC1 (Homo sapiens) | 6480464 | CTD | [GCLC protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; [MYCN protein affects the expression of ABCC1 mRNA] which affects the susceptibility to Etoposide; GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; hesperetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; naringenin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Resveratrol inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Silymarin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Tocopherols inhibits the reaction [ABCC1 protein affects the export of Etoposide]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide] | PMID:10348353 PMID:10900222 PMID:15180633 PMID:15617835 PMID:16156793 | | ||||||||||||||||||||||
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