GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcc1 | affects export | ISO | ABCC1 (Homo sapiens) | 6480464 | CTD | ABCC1 protein affects the export of Daunorubicin | PMID:15498506 | Abcc1 | affects response to substance | ISO | ABCC1 (Homo sapiens) | 6480464 | CTD | ABCC1 affects the susceptibility to Daunorubicin; ABCC1 protein affects the susceptibility to Daunorubicin | PMID:12174371 PMID:18451141 PMID:9096673 PMID:9334814 | Abcc1 | decreases response to substance | ISO | Abcc1 (Mus musculus) | 6480464 | CTD | ABCC1 results in decreased susceptibility to Daunorubicin | PMID:8968083 | Abcc1 | decreases response to substance | ISO | ABCC1 (Homo sapiens) | 6480464 | CTD | ABCC1 protein results in decreased susceptibility to Daunorubicin; ABCC1 results in decreased susceptibility to Daunorubicin | PMID:12115804 PMID:12657726 PMID:35972551 PMID:7954421 | Abcc1 | decreases uptake | ISO | Abcc1 (Mus musculus) | 6480464 | CTD | ABCC1 protein results in decreased uptake of Daunorubicin | PMID:10856430 | Abcc1 | increases export | ISO | ABCC1 (Homo sapiens) | 6480464 | CTD | ABCC1 protein results in increased export of Daunorubicin | PMID:35972551 | Abcc1 | increases secretion | ISO | ABCC1 (Homo sapiens) | 6480464 | CTD | ABCC1 protein results in increased secretion of Daunorubicin | PMID:12088114 PMID:15041471 | Abcc1 | multiple interactions | ISO | Abcc1 (Mus musculus) | 6480464 | CTD | Daunorubicin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Glucose inhibits the reaction [Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]]; Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]; Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin] | PMID:10856430 | Abcc1 | multiple interactions | ISO | ABCC1 (Homo sapiens) | 6480464 | CTD | [enasidenib inhibits the reaction [ABCC1 protein results in increased export of Daunorubicin]] which results in increased susceptibility to Daunorubicin; [MLN 8237 results in decreased activity of ABCC1 protein] which results in decreased export of Daunorubicin; [MLN 8237 results in decreased activity of ABCC1 protein] which results in increased susceptibility to Daunorubicin; [verlukast results in decreased activity of ABCC1 protein] which results in decreased export of Daunorubicin; Benzbromarone inhibits the reaction [ABCC1 protein results in increased secretion of Daunorubicin]; Camptothecin inhibits the reaction [ABCC1 results in decreased susceptibility to Daunorubicin]; enasidenib inhibits the reaction [ABCC1 protein results in decreased susceptibility to Daunorubicin]; enasidenib inhibits the reaction [ABCC1 protein results in increased export of Daunorubicin]; Folic Acid deficiency inhibits the reaction [ABCC1 protein results in increased secretion of Daunorubicin]; homocamptothecin inhibits the reaction [ABCC1 protein results in increased secretion of Daunorubicin]; PAK 104P inhibits the reaction [ABCC1 protein affects the export of Daunorubicin]; Verapamil inhibits the reaction [ABCC1 protein affects the export of Daunorubicin]; verlukast inhibits the reaction [ABCC1 protein results in increased export of Daunorubicin] | PMID:12088114 PMID:12115804 PMID:15041471 PMID:15498506 PMID:34896433 PMID:35972551 | | ||||||||||||||||||||||
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