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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3112
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc1
Name: ATP binding cassette subfamily C member 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc1decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of ABCC1 mRNAPMID:32736004
Abcc1decreases response to substanceEXP 6480464CTDABCC1 protein results in decreased susceptibility to sodium arsenitePMID:11455017
Abcc1increases expressionEXP 6480464CTDsodium arsenite results in increased expression of ABCC1 mRNA; sodium arsenite results in increased expression of ABCC1 proteinPMID:11455017 PMID:19933942 PMID:21465251 PMID:23137061
Abcc1affects exportISOAbcc1 (Mus musculus)6480464CTDABCC1 protein affects the export of sodium arsenitePMID:15694464
Abcc1affects response to substanceISOABCC1 (Homo sapiens)6480464CTDABCC1 protein affects the susceptibility to sodium arsenitePMID:12731862
Abcc1decreases expressionISOAbcc1 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of ABCC1 mRNAPMID:29108910
Abcc1decreases response to substanceISOAbcc1 (Mus musculus)6480464CTDABCC1 results in decreased susceptibility to sodium arsenitePMID:8968083
Abcc1decreases response to substanceISOABCC1 (Homo sapiens)6480464CTDABCC1 protein results in decreased susceptibility to sodium arsenitePMID:10685512 PMID:11278867 PMID:25202056
Abcc1increases expressionISOAbcc1 (Mus musculus)6480464CTDsodium arsenite results in increased expression of ABCC1 mRNA; sodium arsenite results in increased expression of ABCC1 proteinPMID:15694464 PMID:17003472 PMID:20008137 PMID:25485709 PMID:26443841 PMID:26631322
Abcc1increases expressionISOABCC1 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of ABCC1 mRNAPMID:20339138
Abcc1increases secretionISOAbcc1 (Mus musculus)6480464CTDABCC1 protein results in increased secretion of sodium arsenitePMID:28472378
Abcc1multiple interactionsISOAbcc1 (Mus musculus)6480464CTDIFNG protein promotes the reaction [sodium arsenite results in increased expression of ABCC1 protein]; MT1 gene mutant form inhibits the reaction [sodium arsenite results in increased expression of ABCC1 mRNA]; MT2 gene mutant form inhibits the reaction [sodium arsenite results in increased expression of ABCC1 mRNA]; TGFB1 protein inhibits the reaction [sodium arsenite results in increased expression of ABCC1 protein]PMID:17003472 PMID:25485709
Abcc1multiple interactionsISOABCC1 (Homo sapiens)6480464CTDsodium arsenite promotes the reaction [ABCC1 protein binds to CAPRIN1 protein]PMID:33939924
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